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Year after year in the fields of fine chemicals such as pharmaceuticals and agrochemicals. Besides, optically active building units as a chiral synthon is being desired.
Optically active C3 building units have glycerol skeleton, and asymmetric carbon in C2 position and high reactive functions such as epoxy, chloromethyl, hydroxyl, tosyloxyl groups and so on at both ends. Moreover, these glycidyl derivatives are so widely developed in organic syntheses that they are considered very important and versatile compounds. Also, optically active C4 building units are important as well as C3 ones and they are used for side chain of antibial agent and antibiotics. From these points, our optically active C3 and C4 building units are simple, efficient and desired compounds for asymmetric syntheses.
There have been known no ways to prepare the above C3 and C4 chiral building units cost-effecively on an industrial scale though complicated and skillful organic syntheses from natural compouds such as sugar and amino acids have been reported before.
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We, Biochemistry group in DAISO developed a novel generation of microbial production of optically active C3 and C4 building units based on our microorganisms having high stereoselective activity. This technologies allowed to produce highly optically active 1,2-diols, hydroxybutyrates and their derivatives on an industrial scale.
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Nowadays, the resulting optically active C3 and C4 building units as chiral synthons have been used for development of pharmaceuticals, syntheses of natural compounds, manufacture of new materials and ferro liquid crystals, and applications for physico-chemical researches. DAISO's biotechnologies have supported and combined among petrochemistry, biology, organic chemistry, medicine, pharmacy, agriculture and electronics. We, DAISO hope to be a pioneer generating novel science all over the world. |
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