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Optically Active Substances Fine chemical
Supporting New Drug Discoveries with Various Chiral Technologies
Based on customers’ requests, DAISO has been manufacturing and providing numerous optically active compounds indispensable to development of active pharmaceutical ingredients.
We have been providing industry with optical active alkanediols, epoxides manufactured by optical resolution using both microorganisms and asymmetric catalysts. In addition to receiving a license for manufacturing chiral amino acids and hydroxy acids by optical resolution with chiral amine catalyst in 2001, in 2003 we became licensed for the production of optically active hemiesters, the raw materials of which are meso types of cyclic acid anhydrides.

*1 These are substances that, although they have the same chemical formula, have different three-dimensional and mirror image structures; much like the right and left hands.
Most of the substances like proteins, carbohydrates, nucleic acids and lipids that our body is made of are optically active (substances).Their varying shapes give them differenteffects and functions, thus making them valuable as pharmaceuticals.
Unique Chiral Technologies Support Drug Development
Optical Resolution by Microorganisms
Using cost-effective assimilation method*2 by microorganisms, we manufacture and sell multi-ton scale of optically active alkanediols and tetrahydrofurancarboxylic acid. Also, using an enzymatic method modified by gene-recombinant technology, we perform optical resolution of α-, or β- hydroxycarboxylic acids.

*2 Resolution method where microorganisms grow by the enanitioselective assimilation of undesired half of racemic body as a sole carbon source. The derivatives obtained from them are used as intermediates for active pharmaceutical ingredients such as new antibiotics and anti-AIDS medicine.
Optical Resolution Using Jacobsen's Catalyst
We manufacture optically active epichlorohydrin in industrial scale by kinetic hydrolytic resolution of racemic one using a salen catalyst developed by Prof. Jacobsen.
Optical Resolution Using Jacobsen's Catalyst
Optical Resolution of Racemic Amino Acids
Chiral amino acids or hydroxycarboxylic acids are able to be provided manufactured by optical resolution of anhydrides of racemic amino acids and α-hydroxycarboxylic acids using cinchona alkaloid-type of base catalysts based on technology developed by Prof. Deng.
Optical Resolution of Racemic Amino Acids
Highly Selective Desymmetrization Technology
Chiral hemi-esters*3 are obtained in high yield from mesomeric acid anhydrides*4 by stereoselective addition of alcohol using cinchona alkaloid-type base catalysts based on technology developed by Prof. Deng.

*3 A variety of optically active compounds such as carboxylic acid with amino group or hydroxy group in a γ position and γ-lactone can be synthesized from optically active hemiesters.
*4 A wide range of cyclic acid anhydrides, such as glutaric acid derivatives easily synthesized, are available as raw materials.
Highly Selective Desymmetrization Technology
Products -- Liquid --
name of products CAS No. Packing Size Current
Production
Scale
0.1-
1kg		 20kg 200kg
1 R-1,2-Propanediol 4254-14-2 ○ ○ ○ Tonnes
2 R-Epichlorohydrin 51594-55-9 ○ ○ ○ Tonnes
3 R-Methyl 4-chloro-3-hydroxybutyrate 88496-70-2 ○     Tonnes
4 R-Ethyl 4-chloro-3-hydroxybutyrate 90866-33-4 ○     Tonnes
5 R-Propylene carbonate 16606-55-6 ○ ○ ○ Tonnes
6 R-3-Chloro-1,2-propanediol 57090-45-6 ○ ○ ○ Tonnes
7 R-3-Chloro-1,2-propanediol acetonide 57044-24-3 ○     500kg
8 R-Glycidyl butyrate 60456-26-0 ○     500kg
9 R-Methyl glycidyl ether 64491-70-9 ○     500kg
10 R-Benzyl glycidyl ether 14618-80-5 ○     500kg
11 R-Glycerol acetonide 14347-78-5 ○     500kg
12 R-Allyl glycidyl catechol 66966-19-6 ○ ○   100kg
13 R-3-Methoxy propylene carbonate 185836-34-4 none     100kg
14 R-5-Methoxymethyl-2-oxazolidinone 16606-55-6 ○     100kg
15 R-1,2,4-Butanetriol 70005-99-8 none     100g
16 S-Epichlorohydrin 67843-74-7 ○ ○ ○ Tonnes
17 S-3-Chloro-1,2-propanediol 60827-45-4 ○ ○ ○ Tonnes
18 S-Glycidyl butyrate 65031-96-1 ○     Tonnes
19 S-Ethyl 4-chloro-3-hydroxybutyrate 86728-85-0 ○     Tonnes
20 S-1,2,4-Butanetriol 42890-76-6     ○ Tonnes
21 S-1,2-Propanediol 4254-15-3 none     500kg
22 S-Methyl glycidyl ether 64491-68-5 ○     500kg
23 S-Glycerol acetonide 22323-82-6 ○     500kg
24 S-Benzyl glycidyl ether 16495-13-9 ○     500kg
25 S-3-Chloro-1,2-propanediol acetonide 60456-22-6 ○     500kg
26 S-3-Methoxy propylene carbonate 135682-18-7 ○     100kg
27 S-Glycidyl acetate 65031-95-0 ○     100kg
28 S-Propylene carbonate 51260-39-0 ○     100kg
29 S-3-Hydroxytetrahydrofurane 86087-24-3 ○     100g
Products -- Solid --
name of products CAS No. Availability Current
Production
Scale		 Packing
Size
0.1-
1kg		 30kg >200kg
30 R-Glycidyl nosylate 115314-17-5 ○ ○ ○ Tonnes 30kg/drum
31 R-Glycidyl tosylate 113826-06-5 ○ ○   Tonnes 30kg/drum
32 R-Glycidyl phthalimide -     ○ Tonnes 20kg/drum
33 R-Trityl glycidyl ether 65291-30-7 ○     500kg 30kg/drum
34 R-3-Dimethylamino-1,2-propanediol - ○     500g 30kg/drum
35 S-Glycidyl nosylate 115314-14-2 ○ ○ ○ Tonnes 30kg/drum
36 S-Glycidyl tosylate 70987-78-9 ○ ○ ○ Tonnes 50kg/drum
37 S-Glycidyl phthalimide -     ○ Tonnes 20kg/drum
38 S-Trityl glycidyl ether 129940-50-7 ○ ○   500kg 30kg/drum
39 S-3-tert-Butylamino-1,2-propanediol 30315-46-9 ○     100kg 30kg/drum
40 S-3-Dimethylamino-1,2-propanediol - ○     100g 30kg/drum
Contact
chiral@daiso.co.jp
12-18, Awaza 1-chome, Nishi-ku, Osaka 550-0011, Japan
Telephone: +81-6-6110-1598　
Facsimile: +81-6-6110-1612
EUROPE:
silica@daiso.de
chiral@daiso.de
Immermannstrasse 56, 40210, Duesseldorf, Germany
Telephone: +49-(0)211-353146, 353147
Facsimile: +49-(0)211-362286
USA:
t_kitano@daiso.co.jp
2Executive Drive ,Suite 850, FortLee,New Jersey,U.S.A
Telephone: +1-(0)201-292-1850
Facsimile: +1-(0)201-292-1849		 Products Infomation TOP