 |
 |
 |
    |
Based on customers’ requests, DAISO has been manufacturing and providing numerous optically active compounds indispensable to development of active pharmaceutical ingredients.
We have been providing industry with optical active alkanediols, epoxides manufactured by optical resolution using both microorganisms and asymmetric catalysts. In addition to receiving a license for manufacturing chiral amino acids and hydroxy acids by optical resolution with chiral amine catalyst in 2001, in 2003 we became licensed for the production of optically active hemiesters, the raw materials of which are meso types of cyclic acid anhydrides.
*1 These are substances that, although they have the same chemical formula, have different three-dimensional and mirror image structures; much like the right and left hands.
Most of the substances like proteins, carbohydrates, nucleic acids and lipids that our body is made of are optically active (substances).Their varying shapes give them differenteffects and functions, thus making them valuable as pharmaceuticals. |
 |
 |
 |
  |

Using cost-effective assimilation method*2 by microorganisms, we manufacture and sell multi-ton scale of optically active alkanediols and tetrahydrofurancarboxylic acid. Also, using an enzymatic method modified by gene-recombinant technology, we perform optical resolution of α-, or β- hydroxycarboxylic acids.
*2 Resolution method where microorganisms grow by the enanitioselective assimilation of undesired half of racemic body as a sole carbon source. The derivatives obtained from them are used as intermediates for active pharmaceutical ingredients such as new antibiotics and anti-AIDS medicine. |
 |

We manufacture optically active epichlorohydrin in industrial scale by kinetic hydrolytic resolution of racemic one using a salen catalyst developed by Prof. Jacobsen. |
 |
 |

Chiral amino acids or hydroxycarboxylic acids are able to be provided manufactured by optical resolution of anhydrides of racemic amino acids and α-hydroxycarboxylic acids using cinchona alkaloid-type of base catalysts based on technology developed by Prof. Deng. |
 |
 |

Chiral hemi-esters*3 are obtained in high yield from mesomeric acid anhydrides*4 by stereoselective addition of alcohol using cinchona alkaloid-type base catalysts based on technology developed by Prof. Deng.
*3 A variety of optically active compounds such as carboxylic acid with amino group or hydroxy group in a γ position and γ-lactone can be synthesized from optically active hemiesters.
*4 A wide range of cyclic acid anhydrides, such as glutaric acid derivatives easily synthesized, are available as raw materials. |
 |
 |
| Products -- Liquid -- |
|
name of products |
CAS No. |
Packing Size |
Current
Production
Scale |
|
0.1-
1kg |
20kg |
200kg |
| 1 |
R-1,2-Propanediol |
4254-14-2 |
○ |
○ |
○ |
Tonnes |
|
| 2 |
R-Epichlorohydrin |
51594-55-9 |
○ |
○ |
○ |
Tonnes |
|
| 3 |
R-Methyl 4-chloro-3-hydroxybutyrate |
88496-70-2 |
○ |
|
|
Tonnes |
|
| 4 |
R-Ethyl 4-chloro-3-hydroxybutyrate |
90866-33-4 |
○ |
|
|
Tonnes |
|
| 5 |
R-Propylene carbonate |
16606-55-6 |
○ |
○ |
○ |
Tonnes |
|
| 6 |
R-3-Chloro-1,2-propanediol |
57090-45-6 |
○ |
○ |
○ |
Tonnes |
|
| 7 |
R-3-Chloro-1,2-propanediol acetonide |
57044-24-3 |
○ |
|
|
500kg |
|
| 8 |
R-Glycidyl butyrate |
60456-26-0 |
○ |
|
|
500kg |
|
| 9 |
R-Methyl glycidyl ether |
64491-70-9 |
○ |
|
|
500kg |
|
| 10 |
R-Benzyl glycidyl ether |
14618-80-5 |
○ |
|
|
500kg |
|
| 11 |
R-Glycerol acetonide |
14347-78-5 |
○ |
|
|
500kg |
|
| 12 |
R-Allyl glycidyl catechol |
66966-19-6 |
○ |
○ |
|
100kg |
|
| 13 |
R-3-Methoxy propylene carbonate |
185836-34-4 |
none |
|
|
100kg |
|
| 14 |
R-5-Methoxymethyl-2-oxazolidinone |
16606-55-6 |
○ |
|
|
100kg |
|
| 15 |
R-1,2,4-Butanetriol |
70005-99-8 |
none |
|
|
100g |
|
 |
| 16 |
S-Epichlorohydrin |
67843-74-7 |
○ |
○ |
○ |
Tonnes |
|
| 17 |
S-3-Chloro-1,2-propanediol |
60827-45-4 |
○ |
○ |
○ |
Tonnes |
|
| 18 |
S-Glycidyl butyrate |
65031-96-1 |
○ |
|
|
Tonnes |
|
| 19 |
S-Ethyl 4-chloro-3-hydroxybutyrate |
86728-85-0 |
○ |
|
|
Tonnes |
|
| 20 |
S-1,2,4-Butanetriol |
42890-76-6 |
|
|
○ |
Tonnes |
|
| 21 |
S-1,2-Propanediol |
4254-15-3 |
none |
|
|
500kg |
|
| 22 |
S-Methyl glycidyl ether |
64491-68-5 |
○ |
|
|
500kg |
|
| 23 |
S-Glycerol acetonide |
22323-82-6 |
○ |
|
|
500kg |
|
| 24 |
S-Benzyl glycidyl ether |
16495-13-9 |
○ |
|
|
500kg |
|
| 25 |
S-3-Chloro-1,2-propanediol acetonide |
60456-22-6 |
○ |
|
|
500kg |
|
| 26 |
S-3-Methoxy propylene carbonate |
135682-18-7 |
○ |
|
|
100kg |
|
| 27 |
S-Glycidyl acetate |
65031-95-0 |
○ |
|
|
100kg |
|
| 28 |
S-Propylene carbonate |
51260-39-0 |
○ |
|
|
100kg |
|
| 29 |
S-3-Hydroxytetrahydrofurane |
86087-24-3 |
○ |
|
|
100g |
|
 |
| Products -- Solid -- |
|
name of products |
CAS No. |
Availability |
Current
Production
Scale |
Packing
Size |
0.1-
1kg |
30kg |
>200kg |
| 30 |
R-Glycidyl nosylate |
115314-17-5 |
○ |
○ |
○ |
Tonnes |
30kg/drum |
| 31 |
R-Glycidyl tosylate |
113826-06-5 |
○ |
○ |
|
Tonnes |
30kg/drum |
| 32 |
R-Glycidyl phthalimide |
- |
|
|
○ |
Tonnes |
20kg/drum |
| 33 |
R-Trityl glycidyl ether |
65291-30-7 |
○ |
|
|
500kg |
30kg/drum |
| 34 |
R-3-Dimethylamino-1,2-propanediol |
- |
○ |
|
|
500g |
30kg/drum |
 |
| 35 |
S-Glycidyl nosylate |
115314-14-2 |
○ |
○ |
○ |
Tonnes |
30kg/drum |
| 36 |
S-Glycidyl tosylate |
70987-78-9 |
○ |
○ |
○ |
Tonnes |
50kg/drum |
| 37 |
S-Glycidyl phthalimide |
- |
|
|
○ |
Tonnes |
20kg/drum |
| 38 |
S-Trityl glycidyl ether |
129940-50-7 |
○ |
○ |
|
500kg |
30kg/drum |
| 39 |
S-3-tert-Butylamino-1,2-propanediol |
30315-46-9 |
○ |
|
|
100kg |
30kg/drum |
| 40 |
S-3-Dimethylamino-1,2-propanediol |
- |
○ |
|
|
100g |
30kg/drum |
|
 |
Contact
chiral@daiso.co.jp
12-18, Awaza 1-chome, Nishi-ku, Osaka 550-0011, Japan
Telephone: +81-6-6110-1598
Facsimile: +81-6-6110-1612 |
EUROPE:
silica@daiso.de
chiral@daiso.de
Immermannstrasse 56, 40210, Duesseldorf, Germany
Telephone: +49-(0)211-353146, 353147
Facsimile: +49-(0)211-362286 |
USA:
t_kitano@daiso.co.jp
2Executive Drive ,Suite 850, FortLee,New Jersey,U.S.A
Telephone: +1-(0)201-292-1850
Facsimile: +1-(0)201-292-1849 |
 |
|
 |
|